Journal Publications

2017

Jessica L. Ungerleider*, Jacquelin Kammeyer*, Rebecca Braden, Karen L. Christman**, and Nathan C. Gianneschi**. Enzyme-targeted nanoparticles for delivery to ischemic skeletal muscle. Polymer Chemistry. 2017; in press. *Shared first author. **Co-corresponding authors. Pioneering Investigators issue.

Nikhil Rao, Gillie Agmon, Matthew T. Tierney, Jessica L. Ungerleider, Rebecca Braden, Alessandra Sacco, and Karen L. Christman. Engineering an injectable muscle-specific microenvironment for improved cell delivery using a nanofibrous extracellular matrix hydrogel. ACS Nano. 2017; in press.

Raymond M. Wang*, Todd D. Johnson*, Jingjin He, Zhili Rong, Michelle Wong, Vishal Nigam, Atta Behfar, Yang Xu, and Karen L. Christman. Humanized mouse model for assessing the human immune response to Xenogeneic and Allogeneic Biomaterials.  Biomaterials. 2017; in press. *Shared first author.

Melissa J. Hernandez, Karen L. Christman. Designing acellular injectable biomaterial therapeutics for treating myocardial infarction and peripheral artery disease.  Journal of the American College of Cardiology: Basic to Translational Science. 2017; 2: 212-226.

2016

Kristin M. French, Joshua T. Maxwell, Shrishti Bhutani, Shohini Ghosh-Choudhary, Marcos J. Fierro, Todd D. Johnson, Karen L. Christman, W. Robert Taylor, and Michael E. Davis. Fibronectin and cyclic strain improve cardiac progenitor cell regenerative potential in vitro. Stem Cells International. 2016; 2016:8364382. 

Jean W. Wassenaar,  Rebecca L. Braden, Kent G. Osborn, .and Karen L. Christman. Modulating in vivo degradation rate of injectable extracellular matrix hydrogelsJournal of Materials Chemistry B. 2016; 4:2794-2802.

Gillie Agmon and Karen L. Christman. Controlling stem cell behavior with decellularized extracellular matrix scaffolds. Current Opinion in Solid State and Materials Science. 2016; 20:193-201. 

Jessica L. Ungerleider*, Todd D. Johnson*, Melissa J. Hernandez, Dean I. Elhag, Rebecca L. Braden, Monika Dzieciatkowska, Kent G. Osborn, Kirk C. Hansen, Ehtisham Mahmud, Karen L. Christman. Extracellular matrix hydrogel promotes tissue remodeling, arteriogenesis, and perfusion in a rat hindlimb ischemia model. Journal of the American College of Cardiology: Basic to Translational Science. 2016; 1: 32-44. *Shared first author.

Jean W. Wassenaar, Roberto Gaetani, Julian Garcia, Rebecca L. Braden, Colin Luo, Diane Huang, Anthony N. DeMaria, Jeffrey H. Omens, and Karen L. Christman. Transcriptional and histological evidence for the mechanisms underlying the functional benefits of a myocardial matrix hydrogel for post-myocardial infarction treatment. Journal of the American College of Cardiology. 2016; 67:1074-86.

Sophia L. Suarez, Adam Muñoz, Aaron Mitchell, Rebecca L. Braden, Colin Luo, Jennifer R. Cochran, Adah Almutairi*, and Karen L. Christman*. Degradable acetalated dextran microparticles for tunable release of an engineered hepatocyte growth factor fragment. ACS Biomaterials Science & Engineering. 2016; 2:197-204. *Co-corresponding authors.

Roberto Gaetani, Christopher Yin, Neha Srikumar, Rebecca Braden, Pieter A. Doevendans, Joost P. Sluijter, and Karen L. Christman.  Cardiac derived extracellular matrix enhances cardiogenic properties of human cardiac progenitor cells. Cell Transplantation. 2016; 25:1653-63. 

Todd D. Johnson*, Ryan C. Hill*, Monika Dzieciatkowska, Vishal Nigam, Atta Behfar, Karen L. Christman**, and Kirk C. Hansen**. Quantification of decellularized human myocardial matrix: a comparison of six patients. Proteomics Clinical Applications. 2016; 10:75-83 *Shared first author. **Co-corresponding authors.

Raymond M. Wang and Karen L. Christman. Decellularized myocardial matrix hydrogels: in basic research and preclinical studies. Advanced Drug Delivery Reviews. 2016; 96:77-82.

2015

Sophia Suarez, Aboli A. Rane, Adam Munoz, Adam T. Wright, Shirley X. Zhang, Rebecca L. Braden, Adah Almutairi*, Andrew McCulloch, and Karen L. Christman*Intramyocardial injection of hydrogel with high interstitial spread does not impact action potential propagation. Acta Biomaterialia. 2015; 26:13-22. *Co-corresponding authors.

Mary M. Nguyen*, Andrea S. Carlini*, Miao-Ping Chien, Sonya Sonnenberg, Colin Luo, Rebecca L. Braden, Kent G. Osborn, Yiwen Li, Nathan C. Gianneschi**, and Karen L. Christman**.  Enzyme-reponsive nanoparticles for targeted accumulation and prolonged retention in heart tissue after myocardial infarction. Advanced Materials. 2015; 27:5447-52. *Shared first author. **Co-corresponding authors.

Jean W. Wassenaar, Gerry R. Boss*, and Karen L. Christman*.  Decellularized skeletal muscle as an in vitro model for studying drug-extracellular matrix interactions. Biomaterials. 2015; 64: 108-14. *Co-corresponding authors.

Roberto Gaetani, Dries AM Feyen, Vera Verhage, Rolf Slaats,  Elisa Messina,  Karen L. Christman,  Alessandro Giacomello, Pieter AFM Doevendans, and Joost P.G. Sluijter. Epicardial application of cardiac progenitor cells in a 3D-printed gelatin/hyaluronic acid patch preserves cardiac function after myocardial infarction. Biomaterials. 2015; 61:339-48.

Nick Merna, Kelsey M. Fung, Jean J. Wang, Cristi R. King, Kirk C. Hansen, Karen L. Christman, and Steven C. George. Differential β3 Integrin Expression Regulates the Response of Human Lung and Cardiac Fibroblasts to Extracellular Matrix and Its Components.  Tissue Engineering. 2015; 21: 2195-205.

Gregory N. Grover, Julian Garcia, Mary M. Nguyen, Matthew Zanotelli, Michael M. Madani, and Karen L. Christman. Binding of anti-cell adhesive oxime-crosslinked PEG hydrogels to cardiac tissues. Advanced Healthcare Materials. 2015; 4:1327-31.

Jessica L. Ungerleider, Todd D. Johnson, Nikhil Rao, and Karen L. Christman. Fabrication and characterization of injectable hydrogels derived from decellularized skeletal muscle and cardiac muscle. Methods. 2015; 84: 53-9.

Mary M. Nguyen, Nathan C. Gianneschi, and Karen L. Christman. Developing injectable nanomaterials to repair the heart. Current Opinion in Biotechnology. 2015; 34: 225-31. 

Sophia Suarez, Adah Almutairi*, and Karen L. Christman*. Micro- and nanoparticles for treating cardiovascular disease. Biomaterials Science. 2015; 3: 564-80. 
Cover article. 
*Co-corresponding authors.

Sonya Sonnenberg, Aboli A. Rane, Cassie J. Liu, Nikhil Rao, Gillie Agmon, Sophia Suarez, Raymond Wang, Adam Munoz, Vaibhav Bajaj, Shirley Zhang, Rebecca Braden, Pamela J. Schup-Magoffin, Oi Ling Kwan, Anthony N. DeMaria, Jennifer R. Cochran, and Karen L. Christman. Delivery of an engineered HGF fragment in an extracellular matrix-derived hydrogel prevents negative LV remodeling post-myocardial infarction. Biomaterials. 2015; 45:56-63.

2014

Todd D. Johnson, Rebecca Braden, and Karen L. Christman. Injectable ECM scaffolds for cardiac repair. Methods in Molecular Biology. 2014; 1181: 109-20.

Jessica Ungerleider and Karen L. Christman. Injectable biomaterials for the treatment of myocardial infarction and peripheral artery disease: translational challenges and progress. Stem Cells Translational Medicine. 2014: 3: 1090-9. 

D. Adam Young, Vaibhav Bajaj, and Karen L. Christman. Decellularized adipose matrix hydrogels stimulate in vivo neovascularization and adipose formation. Journal of Biomedical Materials Research Part A. 2014; 102: 1641-51. 

Todd D. Johnson,  Jessica A. DeQuach, Roberto Gaetani, Jessica Ungerleider, Dean Elhag, Vishal Nigam, Atta Behfar, and 
Karen L. Christman. Human versus porcine tissue sourcing for an injectable myocardial matrix. Biomaterials Science; 2: 735-44. Emerging Investigators Issue.

Gregory N. Grover, Nikhil Rao, and Karen L. Christman. Myocardial matrix-polyethylene glycol hybrid hydrogels for tissue engineering. Nanotechnology. 2014; 25:014011. 25th anniversary issue.

2013


Sophia Suarez, Gregory Grover, Rebecca Braden, Karen L. Christman*, and Adah Almutairi*. Tunable protein release from acetalated dextran microparticles: a platform for delivery of protein therapeutics to the heart post-MI. Biomacromolecules. 2013; 14:3927-35. *Co-corresponding authors.

Nikhil Rao, Gregory N. Grover, Ludovic G. Vincent, Samantha C. Evans, Yu Suk Choi, Ludovic G. Vincent, Katrina H. Spencer, Elliot E. Hui, Adam J. Engler, and Karen L. Christman. A co-culture device with a tunable stiffness to understand combinatorial cell-cell and cell-matrix interactions. Integrative Biology. 2013; 5: 1344-54. Inside cover article.

D. Adam Young, Yu Suk Choi, Adam J. Engler, and Karen L. Christman. Stimulation of adipogenesis of adult adipose-derived stem cells using substrates that mimic the stiffness of adipose tissue. Biomaterials. 2013; 34: 8581-88.

Milica Radisic and Karen L. Christman. Material Science and Tissue Engineering: Repairing the Heart. Mayo Clinic Proceedings. 2013; 88:884-98.

Jennifer L. Young, Jeremy Tuler, Rebecca Braden, Pamela Schup-Magoffin, Jacquelyn Schaefer, Kyle Kretchmer, Karen L. Christman, and Adam J. Engler. In vivo response to dynamic hyaluronic acid hydrogels. Acta Biomaterialia. 2013; 9:7151-57.

Gregory N. Grover, Rebecca L. Braden, and Karen L. Christman. Oxime cross-linked injectable hydrogels for catheter delivery. Advanced Materials. 2013; 25:2937-42. Back cover article.

Sonya B. Seif-Naraghi*, Jennifer M. Singelyn*, Michael A. Salvatore, Kent G. Osborn, Jean J. Wang, Unatti Sampat, Oi Ling Kwan, G. Monet Strachan, Jonathan Wong, Pamela J. Schup-Magoffin, Rebecca L. Braden, Kendra Bartels, Jessica A. DeQuach, Mark Preul, Adam M. Kinsey, Anthony N. DeMaria, Nabil Dib, and Karen L. Christman. Safety and efficacy of an injectable extracellular matrix hydrogel for treating myocardial infarction. Science Translational Medicine. 2013; 5:173ra25. *Shared first author

Todd D. Johnson and Karen L. Christman. Injectable hydrogel therapies and their delivery strategies for treating myocardial infarction. Expert Opinion on Drug Delivery. 2013; 10:59-72.

Nikhil Rao, Samantha Evans, Danique Stewart, Katrina H. Spencer, Farah Sheikh, Elliot E. Hui, and Karen L. Christman. Fibroblasts influence muscle progenitor differentiation and alignment in contact independent and dependent manners in organized co-culture devices. Biomedical Microdevices. 2013; 15:161-9.

2012

Kristin M. French, Archana V. Boopathy, Jessica A. DeQuach, Loice Chingozha, Hang Lu, Karen L. Christman, and Michael E. Davis. A naturally derived cardiac extracellular matrix enhances cardiac progenitor cell behavior in vitro. Acta Biomaterialia. 2012; 8:4357-64.

Karen L. Christman. Treating the Leading Killer. Science Translational Medicine. 2012; 4:146fs26.

Sonya B. Seif-Naraghi, Dinah Horn, Pam A. Schup-Magoffin, and Karen L. Christman. Injectable Extracellular Matrix Derived Hydrogel Provides a Platform for Enhanced Retention and Delivery of a Heparin Binding Growth Factor. Acta Biomaterialia. 2012; 8:3695-703.

Jessica A. DeQuach, Joy E. Lin, Cynthia Cam, Diane Hu, Michael A. Salvatore, Farah Sheikh, and Karen L. Christman. Injectable Skeletal Muscle Matrix Hydrogel Promotes Neovascularization and Muscle Cell Infiltration in a Hindlimb Ischemia Model. European Cells & Materials. 2012; 23:400-12.

D. Adam Young and Karen L. Christman. Injectable Biomaterials for Adipose Tissue Engineering. Biomedical Materials. 2012; 024104.

Jennifer M. Singelyn, Priya Sundaramurthy, Todd D. Johnson Pamela J. Schup-Magoffin, Diane P. Hu, Denver M. Faulk, Jean Wang, Kristine M. Mayle, Kendra Bartels, Michael Salvatore, Adam M. Kinsey, Anthony N. DeMaria, Nabil Dib, and Karen L. Christman. Catheter-deliverable hydrogel derived from decellularized ventricular extracellular matrix increases endogenous cardiomyocytes and preserves cardiac function post-myocardial infarction. Journal of the American College of Cardiology. 2012; 59:751-63.

Airong Song, Aboli A. Rane, Karen L. Christman. Antibacterial and Cell-adhesive Polypeptide and Poly(ethylene glycol) Hydrogel as a Potential Scaffold for Wound Healing. Acta Biomaterialia. 2012; 8:41-50.

2011

Aboli A. Rane and Karen L. Christman. Biomaterials for the Treatment of Myocardial Infarction: A 5-year Update. Journal of the American College of Cardiology. 2011; 58:2615-29.

Jessica A. DeQuach, Shauna H. Yuan, Lawrence S. B. Goldstein, Karen L. Christman. Decellularized Porcine Brain Matrix for Cell Culture and Tissue Engineering Scaffolds. Tissue Engineering Part A. 2011; 21-22:2583-92.

Todd D. Johnson, Stephen Y. Lin, Karen L. Christman. Tailoring material properties of a nanofibrous extracellular matrix derived hydrogel. Nanotechnology. 2011; 22: 494015.

Aboli A. Rane, Joyce S. Chuang, Amul Shah, Diane P. Hu, Nancy D. Dalton, Yusu Gu, Kirk L. Peterson, Jeffrey H. Omens, and Karen L. Christman. Increased infarct wall thickness by a bio-inert material is insufficient to prevent negative left ventricular remodeling after myocardial infarction. PLoS One. 2011; 6:e21571.

Sonya B. Seif-Naraghi, Dinah Horn, Pam A. Schup-Magoffin, Michael M. Madani, Karen L. Christman. Patient-to-Patient Variability in Autologous Pericardial Matrix Scaffolds for Cardiac Repair. Journal of Cardiovascular Translational Research. 2011; 4:545-56.

Jennifer M. Singelyn and Karen L. Christman. Modulation of material properties of a decellularized myocardial matrix scaffold. Macromolecular Bioscience. 2011; 11:731-8.

Karen L. Christman, Rebecca Broyer, Eric Schopf, Chris Koldoziej, Yong Chen, and Heather Maynard. Protein Nanopatterns by Oxime Bond Formation. Langmuir. 2011; 27:1415-8.

D. Adam Young, Jessica DeQuach, Karen L. Christman. Human Cardiomyogenesis and the Need for Systems Biology Analysis. WIREs Systems Biology and Medicine. 2011; 3:666-80.

2010

D. Adam Young, Diane Hu, and Karen L. Christman. Minimally-Invasive Injectable Hydrogel Scaffold from Decellularized Human Lipoaspirate. Acta Biomaterialia. 2010; 7:1040-9.

Sonya B. Seif-Naraghi, Jennifer M. Singelyn, Jessica A. DeQuach, Pam J. Schup-Magoffin, Karen L. Christman. Fabrication of Biologically Derived Injectable Materials for Myocardial Tissue Engineering. Journal of Visualized Experiments. 2010; 46: e2109.

Kevin Chung, Jessica A. DeQuach, and Karen L. Christman. Nanopatterned Interfaces for Controlling Cell Behavior. Nano-LIFE. 2010; 1:63-77.

Jessica A. DeQuach, Valeria Mezzano, Amar Miglani, Stephan Lange, Gordon M. Keller, Farah Sheikh, and Karen L. Christman. Simple and High Yielding Method for Preparing Tissue Specific Extracellular Matrix Coatings for Cell Culture. PLoS One. 2010; 5:e13039.

Jennifer M. Singelyn and Karen L. Christman. Injectable Materials for the Treatment of Myocardial Infarction and Heart Failure: the Promise of Decellularized Matrices. Journal of Cardiovascular Translational Research. 2010; 3:478-86.

Sonya B. Seif-Naraghi, Michael A. Salvatore, Pamela J. Schup-Magoffin, Diane P. Hu, and Karen L. Christman. Design and Characterization of an Injectable Pericardial Matrix Gel: A Potentially Autologous Scaffold for Cardiac Tissue Engineering. Tissue Engineering Part A. 2010; 16:2017-27.

2009

Jennifer M. Singelyn*, Jessica A. DeQuach*, Sonya Seif-Naraghi, Robert B. Littlefield, Pamela J. Schup-Magoffin, and Karen L. Christman. Naturally Derived Myocardial Matrix As an Injectable Scaffold for Cardiac Tissue Engineering. Biomaterials. 2009; 30:5409-5416. *Shared first author

Karen L. Christman, Eric Schopf, Rebecca M. Broyer, Ronald C. Li, Yong Chen, and Heather D. Maynard. Positioning Multiple Proteins at the Nanoscale with Electron Beam Cross-Linked Functional Polymers. Journal of the American Chemical Society. 2009; 131:521-527. (F1000 Factor 9.0)

Jiashing Yu, Karen L. Christman, Hubert H. Fok, Qizhi Fang, Richard E. Sievers, Anne J. Kim, and Randall J. Lee. Restoration of Left Ventricular Geometry and Improvement of Left Ventricular Function in a Rodent Model of Chronic Ischemic Cardiomyopathy. Journal of Thoracic and Cardiovascular Surgery. 2009; 137:180-187.

2008

Karen L. Christman, Vimary Vazquez-Dorbatt, Eric Schopf, Christopher M. Kolodziej, Ronald C. Li, Rebecca M. Broyer, Yong Chen, and Heather D. Maynard. Nanoscale Growth Factor Patterns by Immobilization on a Heparin-Mimicking Polymer. Journal of the American Chemical Society. 2008; 130:16585-16591.

2007

Paula M. Mendes, Karen L. Christman, Puru Parthasarathy, Eric Schopf, Jianyong Ouyang, Yang Yang, Jon A. Preece, Heather D. Maynard, Yong Chen, J. Fraser Stoddart. Electrochemically Controllable Self-Assembly of Proteins: Spatial Surface Bioconjugation. Bioconjugate Chemistry. 2007; 18, 1919-1923.

Karen L. Christman,* Rebecca M. Broyer,* Zachary P. Tolstyka, and Heather D. Maynard. Site-specific Protein Immobilization through N-terminal Oxime Linkages. Journal of Materials Chemistry. 2007; 17, 2021-2027. *Shared first author.

Branden Brough*, Karen L. Christman*, Tak Sing Wong, Chris M. Kolodziej, Jeffrey G. Forbes, Kuan Wang, Heather D. Maynard, and Chih-Ming Ho. Surface Initiated Actin Polymerization from Top-down Manufactured Nanopatterns. Soft Matter. 2007; 3: 541-546. *Shared first author. (Cover article)

2006

Karen L. Christman, Vanessa D. Enriquez-Rios, and Heather D. Maynard. Nanopatterning Proteins and Peptides. Soft Matter. 2006; 2: 928-939. (September 2009: One of the top 5 most cited biological Soft Matter articles since the journal launched in 2005)

Karen L. Christman, Michael V. Requa, Vanessa D. Enriquez-Rios, Sabrina Ward, Kenneth A. Bradley, Kimberly L. Turner and Heather D. Maynard. Submicron Streptavidin Patterns for Protein Assembly. Langmuir. 2006; 22:7444 -7450.

Karen L. Christman and Randall J. Lee. Biomaterials for Treatment of Myocardial Infarction. Journal of the American College of Cardiology. 2006; 48:907-913.

2005

Karen L. Christman and Heather D. Maynard. Protein Micropatterns Using a pH-Responsive Polymer and Light. Langmuir. 2005; 21:8389-8393.

Karen L. Christman, Qizhi Fang, Anne J. Kim, Richard E. Sievers, Hubert H. Fok, Albert F. Candia, Kenneth J. Colley, Gonzalo Herradon, Laura Ezquerra, Thomas F. Deuel, and Randall J. Lee. Pleiotrophin Induces Formation of Functional Neovasculature In Vivo. Biochemical and Biophysical Research Communications. 2005; 332:1146-1152.

Karen L. Christman, Qizhi Fang, Michael S. Yee, Kandice R. Johnson, Richard E. Sievers, and Randall J. Lee. Enhanced Neovasculature Formation in Ischemic Myocardium Following Delivery of Pleiotrophin Plasmid in a Biopolymer. Biomaterials. 2005; 26:1139-44.

2004

Karen L. Christman, Andrew J. Vardanian, Qizhi Fang, Richard E. Sievers, Hubert H. Fok, and Randall J. Lee. Injectable Fibrin Scaffold Improves Cell Transplant Survival, Reduces Infarct Expansion, and Induces Neovasculature Formation in Ischemic Myocardium. Journal of the American College of Cardiology. 2004; 44:654-60.

Karen L. Christman, Hubert H. Fok, Richard E. Sievers, Qizhi Fang, and Randall J. Lee. Fibrin Glue Alone and Skeletal Myoblasts in a Fibrin Scaffold Preserve Cardiac Function after Myocardial Infarction. Tissue Engineering. 2004; 10:403-9.

2000

Jubilee R. Stewart, Karen L. Christman, and Catherine O'Brian. Effects of Resveratrol on the Autophosphorylation of Phorbol Ester-Responsive Protein Kinases: Inhibition of Protein Kinase D but Not Protein Kinase C Isozyme Autophosphorylation. Biochemical Pharmacology. 2000; 60(9):1355-9.