Publications
2024
Emma Zelus, Aaron Panduro, Isha Deshmukh, Jacqueline Grime, Marianna Alperin, Andrew M. Vahabzadeh-Hagh[*, Karen L. Christman*. Immunomodulatory Extracellular Matrix Hydrogel Induces Tissue Regeneration in a Model of Partial Glossectomy. Bioactive Materials. 2024; in press. *Co-corresponding author.
Michael Nguyen*, Maria Karkanitsa*, and Karen L. Christman. Design and Translation of Injectable Biomaterials. Nature Reviews Bioengineering. 2024; in press. *Co-first authors.
Tatyanna Henderson, Karen L. Christman, and Marianna Alperin. Regenerative Medicine in Urogynecology: here we are and where we want to be. Urogynecology. 2024; 30:519-527.
Jervaughn D. Hunter, Joshua M. Mesfin, Tanzeel Ahmed, Alexander Chen, Kate Reimold, Arielle Hancko, Rebecca L. Braden, Michael E. Davis, and Karen L. Christman. Myocardial Matrix Hydrogels Mitigate Negative Remodeling and Improve Function in Right Heart Failure Model. Journal of the American College of Cardiology: Basic to Translational Science. 2024; 9:322-328.
R. Hugh F. Bender, Benjamen T. O'Donnell, Bhupinder Shergill, Brittany Q. Pham, Sima Tahmouresie, Celeste N. Sanchez, Damie J. Juat, Michaela M. S. Hatch, Venktesh S. Shirure, Matthew Wortham, Kim-Vy Nguyen-Ngoc, Yesl Jun, Roberto Gaetani, Karen L. Christman, Luc Teyton, Steven C. George, Maike Sander, Christopher C. W. Hughes. A vascularized 3D model of the human pancreatic islet for ex vivo study of immune cell-islet interaction. Biofabrication. 2024; 16:025001.
2023
Karen L. Christman. Extracellular Matrix Biomaterial Therapy for Myocardial Infarction: New Delivery Route and Immunomodulatory Effects. Journal of the American College of Cardiology: Basic to Translational Science. 2023; 8: 955-957.
Miranda D. Diaz*, Rebecca M. Kandell*, Jason R. Wu, Alexander Chen, Karen L. Christman**, Ester J. Kwon**. Infusible Extracellular Matrix Biomaterial Promotes Vascular Integrity and Modulates the Inflammatory Response in Acute Traumatic Brain Injury. Advanced Healthcare Materials 2023; 12, 25. *Shared first author. **Co-corresponding author.
Holly L. Sullivan*, Yifei Liang*, Kendra Worthington, Colin G. Luo, Nathan C. Gianneschi**, Karen L. Christman**. Enzyme-Responsive Nanoparticles for the Targeted Delivery of an MMP Inhibitor to Acute Myocardial Infarction. Biomacromolecules 2023, 24, 11, 4695–4704. *Shared first author. **Co-corresponding author.
Raymond M. Wang., Joshua M. Mesfin., Maria L. Karkanitsa, Emma I. Zelus, Jessica Ungerleider, Yuxue Zhang, Yu Kawakami, Yuko Kawakami, Toshiaki Kawakami, Karen L. Christman. Immunmodulatory Contribution of Mast Cells to the Biomaterial Microenvironment. NPJ Regenerative Medicine, 2023; 8, 53.
Pamela Duran, Francesca Boscolo Sesillo, Mark Cook, Lindsey Burnett, Shawn A. Menefee, Emmy Do, Saya French, Gisselle Zazueta-Damian,5 Monika Dzieciatkowska, Anthony J. Saviola, Manali M. Shah, Clyde Sanvictores, Kent G. Osborn, Kirk C. Hansen, Matthew Shtrahman, Karen L. Christman*, Marianna Alperin*. Proregenerative extracellular matrix hydrogel mitigates pathological alterations of pelvic skeletal muscles after birth injury. Science Translational Medicine, 2023; 15, 707. *Co-corresponding author.
Elizabeth M. Cosgriff-Hernandez, Brian A. Aguado , Belinda Akpa, Gabriella Coloyan Fleming, Erika Moore, Ana Maria Porras, Patrick M. Boyle, Deva D. Chan, Naomi Chesler, Karen L. Christman, Tejal A. Desai, Brendan A.C. Harley, Gregory A. Hudalla, Megan L. Killian, Katharina Maisel, Kristen C. Maitland, Shelly R. Peyton, Beth L. Pruitt, Sarah E. Stabenfeldt , Kelly R. Stevens, Audrey K. Bowden. Equitable Hiring Strategies Towards a Diversified Faculty. Nature Biomedical Engineering, 2023; 7, 961-968.
Alexander Chen*, Joshua M. Mesfin*, Nathan C. Gianneschi, Karen L. Christman. Intravascularly Infusible Biomaterials to Treat Myocardial Infarction. Advanced Materials, 2023; in press. *Shared first author.
Yifei Liang*, Holly L. Sullivan*, Kendal P. Carrow, Joshua M. Mesfin, Joanna Korpanty, Kendra Worthington, Colin G. Luo, Karen L. Christman**, Nathan C. Gianneschi**. Inflammation-responsive micellar nanoparticles from degradable polyphosphoramidates for targeted delivery to myocardial infarction. J. Am. Chem. Soc. 2023, 145, 20, 11185–11194. *Shared first author. **Co-corresponding author.
2022
Martin T. Spang, Ryan Middleton, Miranda Diaz, Jervaughn Hunter, Joshua Mesfin, Alison Banka, Holly Sullivan, Raymond Want, Tori S. Lazerson, Saumya Bhatia, James Corbitt, Gavin D'Elia, Gerardo Sandoval-Gomez, Rebecca Kandell, Maria A Vratsanos, Karthikeyan Gnanasekaran, Takayuki Kato, Sachiyo Igata, Colin Luo, Kent G Osborn, Nathan C. Gianneschi, Omolola Eniola-Adefeso, Pedro Cabrales, Ester J. Kwon, Francisco Contijoch, Ryan R. Reeves, Anthony N. Demaria, Karen L. Christman. Intravascularly Infused Extracellular Matrix as a Biomaterial for Targeting and Treating Inflamed Tissues. Nature Biomedical Engineering, 2023; 7, 94-109.
David M. Calcagno, Nika Taghdiri, Van Ninh, Joshua M. Mesfin, Avinash Toomu, Rahul Sehgal, Jodi Lee, Yan Liang, Jason M. Duran, Eric Adler, Karen L. Christman, Kun Zhang, Farah Sheikh, Zhenxing Fu, Kevin R. King. Single-cell and Spatial Transcriptomics of the Infarcted Heart Define the Dynamic Onset of the Border Zone in Response to Mechanical Destabilization. Nature Cardiovascular Research, 2022; 1, 1039-1055.
Francesca B. Sesillo, Varsha Rajesh, Michelle Wong, Pamela Duran, John B. Rudell, Courtney P. Rundio, Brittni B. Baynes, Louise C. Laurent, Alessandra Sacco, Karen L. Christman, Marianna Alperin. Muscle Stem Cells and Fibro-adipogenic Progenitors in Female Pelvic Floor Muscle Regeneration Following Birth Injury. NPJ Regenerative Medicine, 2022; 7(1):72.
Raymond M. Wang, Joshua M. Mesfin, Jervaughn D. Hunter, Paola Cattaneo, Nuno Guimarães-Gamboa, Rebecca L. Braden, Colin Luo, Ryan C. Hull, Monica Dzieciatkowska, Kirk C. Hansen, Sylvia Evans, Karen L. Christman. Myocardial Matrix Hydrogel Acts as a Reactive Oxygen Species Scavenger and Supports a Proliferative Microenvironment for Cardiomyocytes. Acta Biomaterialia, 2022; 152:47-59
Jervaughn D. Hunter, Arielle Hancko, Preety Sakya, Ryan Hill, Anthony J. Saviola, Kirk C. Hansen, Michael E. Davis. Karen L. Christman. Characterization of Decellularized Left and Right Ventricular Myocardial Matrix Hydrogels and Their Effect on on Cardiac Progenitor Cells. Journal of Molecular and Cellular Cardiology, 2022; 171:45-55.
Jervaughn D. Hunter, Todd D. Johnson, Rebecca L. Braden, Karen L. Christman. Injectable ECM Scaffolds for Cardiac Repair. Methods in Molecular Biology: Cardiac Tissue Engineering, 2022; 255-268.
Donald Bejleri, Matthew J Robeson, Milton E. Brown, Jervaughn D. Hunter., Joshua T. Maxwell, Benjamin W. Streeter, Olga Bazhkina, Hyun-Ji Park, Karen L. Christman., Michael E. Davis. In Vivo Evaluation of Bioprinted Cardiac Patches Composed of Cardiac-Specific Extracellular Matrix and Progenitor Cells in a Model of Pediatric Heart Failure. Biomaterials Science, 2022; 2:309-604
2021
Masaki Fujita, Gina M. Policastro, Austin Burdick, Hillary T. Lam, Jessica L. Ungerleider, Rebecca L. Braden, Diane Huang, Kent G. Osborn, Jeffrey Omens, Michael M. Madani, Karen L. Christman. Preventing Post-surgical Cardiac Adhesions with a Catechol-functionalized Oxime Hydrogel. Nature Communications,, 2021; 12(1):3764.
Mary M. Rieger,* Pamela Duran,* Mark Cook,* Simon Schenk, Manali Shah, Marni Jacobs, Karen L. Christman, Deborah Kado, Marianna Alperin. Quantifying the Effects of Aging on Histomorphologial Properties of Human Female Pelvic Floor Muscle.,ABME. 2021; 49:1836-47. *Shared first author.
Miranda D. Diaz, Elaine Tran, Jean W. Wassenaar, Martin Spang, Roberto Gaetani, Colin G. Luo, Rebecca Braden, Ryan C. Hill, Kirk C. Hansen, Anthony N. DeMaria, Karen L. Christman. Injectable Myocardial Matrix Hydrogel Mitigates Negative Left Ventricular Remodeling in a Chronic Myocardial Infarction Model. JACC: Basic to Translational Science. 2021; 6(4)-350-361.
Kelly R. Stevens, Kristyn S. Masters, P.I. Imoukhuede, Karmella A. Haynes, Lori A. Setton, Elizabeth Cosgriff-Hernandez, Muyinatu A. Lediju Bell, Padmini Rangamani, Shelly E. Sakiyama-Elbert, Stacey D. Finley, Rebecca K. Willits, Abigail N. Koppes, Naomi C. Chesler, Karen L. Christman, Josephine B. Allen, Joyce Y. Wong, Hana El-Samad, Tejal A. Desai, Omolola Eniola-Adefeso. Fund Black Scientists. Cell. 2021; 184(3):561-565.
Holly L. Sullivan, Nathan C. Gianneschi, Karen L. Christman. Targeted nanoscale therapeutics for myocardial infarction. Biomaterials Science. 2021; 9(4)-1204-1216.
2020
Melissa J. Hernandez, Emma I. Zelus, Martin T. Spang, Rebecca L. Braden, and Karen L. Christman. Dose Optimization of Decellularized Skeletal Muscle Extracellular Matrix Hydrogels for Improving Perfusion and Subsequent Validation in an Aged Hindlimb Ischemia Model. Biomaterials Science. 2020; 8:3511-3521.
Melissa J. Hernandez, Grace E. Yakutis, Emma I. Zelus, Ryan C.Hill, Monika Dzieciatkowska, Kirk C. Hansen, Karen L. Christman. Manufacturing Considerations for Producing and Assessing Decellularized Extracellular Matrix Hydrogels. Methods. 2020; 171:20-27.
2019
Pamela Duran, Marianna Alperin, Karen L. Christman. Decellularized Extracellular Matrix Hydrogels: Fabrication, Properties, Characterization, and Current Applications. Decellularized Extracellular Matrix: Characterization, Fabrication and Applications. 2019; 116-138.
Jay H. Traverse, Timothy D. Henry, Nabil Dib, Amit N. Patel, Carl Pepine, Gary L. Schaer, Jessica A. DeQuach, Adam M. Kinsey, Paul Chamberlin, Karen L. Christman. First-in-Man Study of a Cardiac Extracellular Matrix Hydrogel in Early and Late Myocardial Infarction Patients. JACC: Basic to Translational Science. 2019; 4:659-69.
Miranda Diaz, Karen L. Christman. Injectable Hydrogels to Treat Myocardial Infarction. Cardiovascular Regenerative Medicine. 2019; 185-206.
Andrea Carlini, Roberto Gaetani, Rebecca Braden, Colin Luo, Karen L. Christman, and Nathan C. Gianneschi. Enzyme-responsive progelator cyclic peptides for minimally invasive delivery to the heart post-myocardial infarction. Nature Communications. 2019; 10:1735.
Pamela Duran, Samuel R. Ward, Karen L. Christman, and Marianna Alperin. Mechanical impact of parturition-related strains on rat pelvic striated sphincters. Neurourology and Urodynamics. 2019; 38(3):912-919.
Karen L. Christman. Biomaterials for tissue repair. Science 2019; 363.6425:340-341.
Vipul Sheth, Pamela Duran, Jonathan Wong, Sameer Shah, Jiang Du, Karen L. Christman, Eric Y. Chang, and Marianna Alperin. Multimodal imaging assessment and histologic correlation of the female rat pelvic floor muscles' anatomy. Journal of Anatomy. 2019; 234:543-550.
2018
Donald Bejleri, Benjamin W. Streeter, Aline L.Y. Nachlas, Milton E. Brown, Roberto Gaetani, Karen L. Christman, and Michael E. Davis. A bioprinted cardiac patch composed of cardiac‐specific extracellular matrix and progenitor cells for heart repair. Advanced Healthcare Materials. 2018; 7:1800672.
Roberto Gaetani, Soraya Aouad, Lea L. Demaddalena, Heinz Straessle, Monika Dzieciatkowska, Matthew Wortham, Hugh R.T. Bender Kim-Vy Nguyen-Ngoc, Geert W. Schmid-Schoenbein, Steven C. George, Christopher C.W. Hughes, Maike Sander, Kirk C. Hansen, and Karen L. Christman. Evaluation of different decellularization protocols on the generation of pancreas-derived hydrogels. Tissue Engineering Part C. 2018; 24(12):697-708.
Melissa J. Hernandez*, Roberto Gaetani*, Vera M. Pieters, Nathan W. Ng, Audrey E. Chang, Taylor R. Martin, Eva van Ingen, Monika Dzieciatkowska, Kirk C. Hansen, Joost P.G. Sluijter, and Karen L. Christman. Decellularized extracellular matrix hydrogels as a delivery platform for microRNA and extracellular vesicle therapeutics. Advanced Therapeutics. 2018; 1:1800032. *Shared first author.
Martin T. Spang and Karen L. Christman. Extracellular matrix hydrogel therapies: in vivo applications and development. Acta Biomaterialia. 2018; 68:1-14.
Adam D. Young, Brian Mailey, Jennifer Baker, Anne M. Wallace, and Karen L. Christman. Adipose tissue engineering and stem cells. Engineering Stem Cells for Tissue Regeneration. 2018; 8:185-212.
2017
Yue Zhang, Weiwei Gao, Yijie Chen, Tamara Escajadillo, Jessica L. Ungerleider, Ronnie H. Fang, Karen L. Christman, Victor Nizet, and Liangfang Zhang. Self-assembled colloidal gel using cell membrane-coated nanosponges as building blocks. ACS Nano. 2017; 11:11923-11930.
Raymond M. Wang, Jingjin He, Yang Xu, and Karen L. Christman. Humanized mouse model for evaluating biocompatibility and human immune cell interactions to biomaterials. Drug Discovery Today: Disease Models. 2017; 24:23-29.
Jessica L. Ungerleider*, Jacquelin Kammeyer*, Rebecca Braden, Karen L. Christman**, and Nathan C. Gianneschi**. Enzyme-targeted nanoparticles for delivery to ischemic skeletal muscle. Polymer Chemistry. 2017; 8:5212-5219. *Shared first author. **Co-corresponding authors. Pioneering Investigators issue.
Nikhil Rao, Gillie Agmon, Matthew T. Tierney, Jessica L. Ungerleider, Rebecca Braden, Alessandra Sacco, and Karen L. Christman. Engineering an injectable muscle-specific microenvironment for improved cell delivery using a nanofibrous extracellular matrix hydrogel. ACS Nano. 2017; 11:3851-3859.
Raymond M. Wang*, Todd D. Johnson*, Jingjin He, Zhili Rong, Michelle Wong, Vishal Nigam, Atta Behfar, Yang Xu, and Karen L. Christman. Humanized mouse model for assessing the human immune response to Xenogeneic and Allogeneic Biomaterials. Biomaterials. 2017; 129:98-110. *Shared first author.
Melissa J. Hernandez, Karen L. Christman. Designing acellular injectable biomaterial therapeutics for treating myocardial infarction and peripheral artery disease. Journal of the American College of Cardiology: Basic to Translational Science. 2017; 2:212-226.
2016
Kristin M. French, Joshua T. Maxwell, Shrishti Bhutani, Shohini Ghosh-Choudhary, Marcos J. Fierro, Todd D. Johnson, Karen L. Christman, W. Robert Taylor, and Michael E. Davis. Fibronectin and cyclic strain improve cardiac progenitor cell regenerative potential in vitro. Stem Cells International. 2016; 2016:8364382.
Jean W. Wassenaar, Rebecca L. Braden, Kent G. Osborn, and Karen L. Christman. Modulating in vivo degradation rate of injectable extracellular matrix hydrogels. Journal of Materials Chemistry B. 2016; 4:2794-2802.
Gillie Agmon and Karen L. Christman. Controlling stem cell behavior with decellularized extracellular matrix scaffolds. Current Opinion in Solid State and Materials Science. 2016; 20:193-201.
Jessica L. Ungerleider*, Todd D. Johnson*, Melissa J. Hernandez, Dean I. Elhag, Rebecca L. Braden, Monika Dzieciatkowska, Kent G. Osborn, Kirk C. Hansen, Ehtisham Mahmud, and Karen L. Christman. Extracellular matrix hydrogel promotes tissue remodeling, arteriogenesis, and perfusion in a rat hindlimb ischemia model. Journal of the American College of Cardiology: Basic to Translational Science. 2016; 1: 32-44. *Shared first author.
Jean W. Wassenaar, Roberto Gaetani, Julian Garcia, Rebecca L. Braden, Colin Luo, Diane Huang, Anthony N. DeMaria, Jeffrey H. Omens, and Karen L. Christman. Transcriptional and histological evidence for the mechanisms underlying the functional benefits of a myocardial matrix hydrogel for post-myocardial infarction treatment. Journal of the American College of Cardiology. 2016; 67:1074-86.
Sophia L. Suarez, Adam Muñoz, Aaron Mitchell, Rebecca L. Braden, Colin Luo, Jennifer R. Cochran, Adah Almutairi*, and Karen L. Christman*. Degradable acetalated dextran microparticles for tunable release of an engineered hepatocyte growth factor fragment. ACS Biomaterials Science & Engineering. 2016; 2:197-204. *Co-corresponding authors.
Roberto Gaetani, Christopher Yin, Neha Srikumar, Rebecca Braden, Pieter A. Doevendans, Joost P. Sluijter, and Karen L. Christman. Cardiac derived extracellular matrix enhances cardiogenic properties of human cardiac progenitor cells. Cell Transplantation. 2016; 25:1653-63.
Todd D. Johnson*, Ryan C. Hill*, Monika Dzieciatkowska, Vishal Nigam, Atta Behfar, Karen L. Christman**, and Kirk C. Hansen**. Quantification of decellularized human myocardial matrix: a comparison of six patients. Proteomics Clinical Applications. 2016; 10:75-83 *Shared first author. **Co-corresponding authors.
Raymond M. Wang and Karen L. Christman. Decellularized myocardial matrix hydrogels: in basic research and preclinical studies. Advanced Drug Delivery Reviews. 2016; 96:77-82.
2015
Sophia Suarez, Aboli A. Rane, Adam Munoz, Adam T. Wright, Shirley X. Zhang, Rebecca L. Braden, Adah Almutairi*, Andrew McCulloch, and Karen L. Christman*. Intramyocardial injection of hydrogel with high interstitial spread does not impact action potential propagation. Acta Biomaterialia. 2015; 26:13-22. *Co-corresponding authors.
Mary M. Nguyen*, Andrea S. Carlini*, Miao-Ping Chien, Sonya Sonnenberg, Colin Luo, Rebecca L. Braden, Kent G. Osborn, Yiwen Li, Nathan C. Gianneschi**, and Karen L. Christman**. Enzyme-reponsive nanoparticles for targeted accumulation and prolonged retention in heart tissue after myocardial infarction. Advanced Materials. 2015; 27:5447-52. *Shared first author. **Co-corresponding authors.
Jean W. Wassenaar, Gerry R. Boss*, and Karen L. Christman*. Decellularized skeletal muscle as an in vitro model for studying drug-extracellular matrix interactions. Biomaterials. 2015; 64: 108-14. *Co-corresponding authors.
Roberto Gaetani, Dries AM Feyen, Vera Verhage, Rolf Slaats, Elisa Messina, Karen L. Christman, Alessandro Giacomello, Pieter AFM Doevendans, and Joost P.G. Sluijter. Epicardial application of cardiac progenitor cells in a 3D-printed gelatin/hyaluronic acid patch preserves cardiac function after myocardial infarction. Biomaterials. 2015; 61:339-48.
Nick Merna, Kelsey M. Fung, Jean J. Wang, Cristi R. King, Kirk C. Hansen, Karen L. Christman, and Steven C. George. Differential β3 Integrin Expression Regulates the Response of Human Lung and Cardiac Fibroblasts to Extracellular Matrix and Its Components. Tissue Engineering. 2015; 21: 2195-205.
Gregory N. Grover, Julian Garcia, Mary M. Nguyen, Matthew Zanotelli, Michael M. Madani, and Karen L. Christman. Binding of anti-cell adhesive oxime-crosslinked PEG hydrogels to cardiac tissues. Advanced Healthcare Materials. 2015; 4:1327-31.
Jessica L. Ungerleider, Todd D. Johnson, Nikhil Rao, and Karen L. Christman. Fabrication and characterization of injectable hydrogels derived from decellularized skeletal muscle and cardiac muscle. Methods. 2015; 84: 53-9.
Mary M. Nguyen, Nathan C. Gianneschi, and Karen L. Christman. Developing injectable nanomaterials to repair the heart. Current Opinion in Biotechnology. 2015; 34: 225-31.
Sophia Suarez, Adah Almutairi*, and Karen L. Christman*. Micro- and nanoparticles for treating cardiovascular disease. Biomaterials Science. 2015; 3: 564-80. Cover article. *Co-corresponding authors.
Sonya Sonnenberg, Aboli A. Rane, Cassie J. Liu, Nikhil Rao, Gillie Agmon, Sophia Suarez, Raymond Wang, Adam Munoz, Vaibhav Bajaj, Shirley Zhang, Rebecca Braden, Pamela J. Schup-Magoffin, Oi Ling Kwan, Anthony N. DeMaria, Jennifer R. Cochran, and Karen L. Christman. Delivery of an engineered HGF fragment in an extracellular matrix-derived hydrogel prevents negative LV remodeling post-myocardial infarction. Biomaterials. 2015; 45:56-63.
2014
Todd D. Johnson, Rebecca Braden, and Karen L. Christman. Injectable ECM scaffolds for cardiac repair. Methods in Molecular Biology. 2014; 1181: 109-20.
Jessica Ungerleider and Karen L. Christman. Injectable biomaterials for the treatment of myocardial infarction and peripheral artery disease: translational challenges and progress. Stem Cells Translational Medicine. 2014: 3: 1090-9.
D. Adam Young, Vaibhav Bajaj, and Karen L. Christman. Decellularized adipose matrix hydrogels stimulate in vivo neovascularization and adipose formation. Journal of Biomedical Materials Research Part A. 2014; 102: 1641-51.
Todd D. Johnson, Jessica A. DeQuach, Roberto Gaetani, Jessica Ungerleider, Dean Elhag, Vishal Nigam, Atta Behfar, and Karen L. Christman. Human versus porcine tissue sourcing for an injectable myocardial matrix. Biomaterials Science; 2: 735-44. Emerging Investigators Issue.
Gregory N. Grover, Nikhil Rao, and Karen L. Christman. Myocardial matrix-polyethylene glycol hybrid hydrogels for tissue engineering. Nanotechnology. 2014; 25:014011. 25th anniversary issue.
2013
Sophia Suarez, Gregory Grover, Rebecca Braden, Karen L. Christman*, and Adah Almutairi*. Tunable protein release from acetalated dextran microparticles: a platform for delivery of protein therapeutics to the heart post-MI. Biomacromolecules. 2013; 14:3927-35. *Co-corresponding authors.
Nikhil Rao, Gregory N. Grover, Ludovic G. Vincent, Samantha C. Evans, Yu Suk Choi, Ludovic G. Vincent, Katrina H. Spencer, Elliot E. Hui, Adam J. Engler, and Karen L. Christman. A co-culture device with a tunable stiffness to understand combinatorial cell-cell and cell-matrix interactions. Integrative Biology. 2013; 5: 1344-54. Inside cover article.
D. Adam Young, Yu Suk Choi, Adam J. Engler, and Karen L. Christman. Stimulation of adipogenesis of adult adipose-derived stem cells using substrates that mimic the stiffness of adipose tissue. Biomaterials. 2013; 34: 8581-88.
Milica Radisic and Karen L. Christman. Material Science and Tissue Engineering: Repairing the Heart. Mayo Clinic Proceedings. 2013; 88:884-98.
Jennifer L. Young, Jeremy Tuler, Rebecca Braden, Pamela Schup-Magoffin, Jacquelyn Schaefer, Kyle Kretchmer, Karen L. Christman, and Adam J. Engler. In vivo response to dynamic hyaluronic acid hydrogels. Acta Biomaterialia. 2013; 9:7151-57.
Gregory N. Grover, Rebecca L. Braden, and Karen L. Christman. Oxime cross-linked injectable hydrogels for catheter delivery. Advanced Materials. 2013; 25:2937-42. Back cover article.
Sonya B. Seif-Naraghi*, Jennifer M. Singelyn*, Michael A. Salvatore, Kent G. Osborn, Jean J. Wang, Unatti Sampat, Oi Ling Kwan, G. Monet Strachan, Jonathan Wong, Pamela J. Schup-Magoffin, Rebecca L. Braden, Kendra Bartels, Jessica A. DeQuach, Mark Preul, Adam M. Kinsey, Anthony N. DeMaria, Nabil Dib, and Karen L. Christman. Safety and efficacy of an injectable extracellular matrix hydrogel for treating myocardial infarction. Science Translational Medicine. 2013; 5:173ra25. *Shared first author
Todd D. Johnson and Karen L. Christman. Injectable hydrogel therapies and their delivery strategies for treating myocardial infarction. Expert Opinion on Drug Delivery. 2013; 10:59-72.
Nikhil Rao, Samantha Evans, Danique Stewart, Katrina H. Spencer, Farah Sheikh, Elliot E. Hui, and Karen L. Christman. Fibroblasts influence muscle progenitor differentiation and alignment in contact independent and dependent manners in organized co-culture devices. Biomedical Microdevices. 2013; 15:161-9.
2012
Kristin M. French, Archana V. Boopathy, Jessica A. DeQuach, Loice Chingozha, Hang Lu, Karen L. Christman, and Michael E. Davis. A naturally derived cardiac extracellular matrix enhances cardiac progenitor cell behavior in vitro. Acta Biomaterialia. 2012; 8:4357-64.
Karen L. Christman. Treating the Leading Killer. Science Translational Medicine. 2012; 4:146fs26.
Sonya B. Seif-Naraghi, Dinah Horn, Pam A. Schup-Magoffin, and Karen L. Christman. Injectable Extracellular Matrix Derived Hydrogel Provides a Platform for Enhanced Retention and Delivery of a Heparin Binding Growth Factor. Acta Biomaterialia. 2012; 8:3695-703.
Jessica A. DeQuach, Joy E. Lin, Cynthia Cam, Diane Hu, Michael A. Salvatore, Farah Sheikh, and Karen L. Christman. Injectable Skeletal Muscle Matrix Hydrogel Promotes Neovascularization and Muscle Cell Infiltration in a Hindlimb Ischemia Model. European Cells & Materials. 2012; 23:400-12.
D. Adam Young and Karen L. Christman. Injectable Biomaterials for Adipose Tissue Engineering. Biomedical Materials. 2012; 024104.
Jennifer M. Singelyn, Priya Sundaramurthy, Todd D. Johnson Pamela J. Schup-Magoffin, Diane P. Hu, Denver M. Faulk, Jean Wang, Kristine M. Mayle, Kendra Bartels, Michael Salvatore, Adam M. Kinsey, Anthony N. DeMaria, Nabil Dib, and Karen L. Christman. Catheter-deliverable hydrogel derived from decellularized ventricular extracellular matrix increases endogenous cardiomyocytes and preserves cardiac function post-myocardial infarction. Journal of the American College of Cardiology. 2012; 59:751-63.
Airong Song, Aboli A. Rane, Karen L. Christman. Antibacterial and Cell-adhesive Polypeptide and Poly(ethylene glycol) Hydrogel as a Potential Scaffold for Wound Healing. Acta Biomaterialia. 2012; 8:41-50.
2011
Aboli A. Rane and Karen L. Christman. Biomaterials for the Treatment of Myocardial Infarction: A 5-year Update. Journal of the American College of Cardiology. 2011; 58:2615-29.
Jessica A. DeQuach, Shauna H. Yuan, Lawrence S. B. Goldstein, Karen L. Christman. Decellularized Porcine Brain Matrix for Cell Culture and Tissue Engineering Scaffolds. Tissue Engineering Part A. 2011; 21-22:2583-92.
Todd D. Johnson, Stephen Y. Lin, Karen L. Christman. Tailoring material properties of a nanofibrous extracellular matrix derived hydrogel. Nanotechnology. 2011; 22: 494015.
Aboli A. Rane, Joyce S. Chuang, Amul Shah, Diane P. Hu, Nancy D. Dalton, Yusu Gu, Kirk L. Peterson, Jeffrey H. Omens, and Karen L. Christman. Increased infarct wall thickness by a bio-inert material is insufficient to prevent negative left ventricular remodeling after myocardial infarction. PLoS One. 2011; 6:e21571.
Sonya B. Seif-Naraghi, Dinah Horn, Pam A. Schup-Magoffin, Michael M. Madani, Karen L. Christman. Patient-to-Patient Variability in Autologous Pericardial Matrix Scaffolds for Cardiac Repair. Journal of Cardiovascular Translational Research. 2011; 4:545-56.
Jennifer M. Singelyn and Karen L. Christman. Modulation of material properties of a decellularized myocardial matrix scaffold. Macromolecular Bioscience. 2011; 11:731-8.
Karen L. Christman, Rebecca Broyer, Eric Schopf, Chris Koldoziej, Yong Chen, and Heather Maynard. Protein Nanopatterns by Oxime Bond Formation. Langmuir. 2011; 27:1415-8.
D. Adam Young, Jessica DeQuach, Karen L. Christman. Human Cardiomyogenesis and the Need for Systems Biology Analysis. WIREs Systems Biology and Medicine. 2011; 3:666-80.
2010
D. Adam Young, Diane Hu, and Karen L. Christman. Minimally-Invasive Injectable Hydrogel Scaffold from Decellularized Human Lipoaspirate. Acta Biomaterialia. 2010; 7:1040-9.
Sonya B. Seif-Naraghi, Jennifer M. Singelyn, Jessica A. DeQuach, Pam J. Schup-Magoffin, Karen L. Christman. Fabrication of Biologically Derived Injectable Materials for Myocardial Tissue Engineering. Journal of Visualized Experiments. 2010; 46: e2109.
Kevin Chung, Jessica A. DeQuach, and Karen L. Christman. Nanopatterned Interfaces for Controlling Cell Behavior. Nano-LIFE. 2010; 1:63-77.
Jessica A. DeQuach, Valeria Mezzano, Amar Miglani, Stephan Lange, Gordon M. Keller, Farah Sheikh, and Karen L. Christman. Simple and High Yielding Method for Preparing Tissue Specific Extracellular Matrix Coatings for Cell Culture. PLoS One. 2010; 5:e13039.
Jennifer M. Singelyn and Karen L. Christman. Injectable Materials for the Treatment of Myocardial Infarction and Heart Failure: the Promise of Decellularized Matrices. Journal of Cardiovascular Translational Research. 2010; 3:478-86.
Sonya B. Seif-Naraghi, Michael A. Salvatore, Pamela J. Schup-Magoffin, Diane P. Hu, and Karen L. Christman. Design and Characterization of an Injectable Pericardial Matrix Gel: A Potentially Autologous Scaffold for Cardiac Tissue Engineering. Tissue Engineering Part A. 2010; 16:2017-27.
2009
Jennifer M. Singelyn*, Jessica A. DeQuach*, Sonya Seif-Naraghi, Robert B. Littlefield, Pamela J. Schup-Magoffin, and Karen L. Christman. Naturally Derived Myocardial Matrix As an Injectable Scaffold for Cardiac Tissue Engineering. Biomaterials. 2009; 30:5409-5416. *Shared first author
Karen L. Christman, Eric Schopf, Rebecca M. Broyer, Ronald C. Li, Yong Chen, and Heather D. Maynard. Positioning Multiple Proteins at the Nanoscale with Electron Beam Cross-Linked Functional Polymers. Journal of the American Chemical Society. 2009; 131:521-527. (F1000 Factor 9.0)
Jiashing Yu, Karen L. Christman, Hubert H. Fok, Qizhi Fang, Richard E. Sievers, Anne J. Kim, and Randall J. Lee. Restoration of Left Ventricular Geometry and Improvement of Left Ventricular Function in a Rodent Model of Chronic Ischemic Cardiomyopathy. Journal of Thoracic and Cardiovascular Surgery. 2009; 137:180-187.
2008
Karen L. Christman, Vimary Vazquez-Dorbatt, Eric Schopf, Christopher M. Kolodziej, Ronald C. Li, Rebecca M. Broyer, Yong Chen, and Heather D. Maynard. Nanoscale Growth Factor Patterns by Immobilization on a Heparin-Mimicking Polymer. Journal of the American Chemical Society. 2008; 130:16585-16591.
2007
Paula M. Mendes, Karen L. Christman, Puru Parthasarathy, Eric Schopf, Jianyong Ouyang, Yang Yang, Jon A. Preece, Heather D. Maynard, Yong Chen, J. Fraser Stoddart. Electrochemically Controllable Self-Assembly of Proteins: Spatial Surface Bioconjugation. Bioconjugate Chemistry. 2007; 18, 1919-1923.
Karen L. Christman,* Rebecca M. Broyer,* Zachary P. Tolstyka, and Heather D. Maynard. Site-specific Protein Immobilization through N-terminal Oxime Linkages. Journal of Materials Chemistry. 2007; 17, 2021-2027. *Shared first author.
Branden Brough*, Karen L. Christman*, Tak Sing Wong, Chris M. Kolodziej, Jeffrey G. Forbes, Kuan Wang, Heather D. Maynard, and Chih-Ming Ho. Surface Initiated Actin Polymerization from Top-down Manufactured Nanopatterns. Soft Matter. 2007; 3: 541-546. *Shared first author. (Cover article)
2006
Karen L. Christman, Vanessa D. Enriquez-Rios, and Heather D. Maynard. Nanopatterning Proteins and Peptides. Soft Matter. 2006; 2: 928-939. (September 2009: One of the top 5 most cited biological Soft Matter articles since the journal launched in 2005)
Karen L. Christman, Michael V. Requa, Vanessa D. Enriquez-Rios, Sabrina Ward, Kenneth A. Bradley, Kimberly L. Turner and Heather D. Maynard. Submicron Streptavidin Patterns for Protein Assembly. Langmuir. 2006; 22:7444 -7450.
Karen L. Christman and Randall J. Lee. Biomaterials for Treatment of Myocardial Infarction. Journal of the American College of Cardiology. 2006; 48:907-913.
2005
Karen L. Christman and Heather D. Maynard. Protein Micropatterns Using a pH-Responsive Polymer and Light. Langmuir. 2005; 21:8389-8393.
Karen L. Christman, Qizhi Fang, Anne J. Kim, Richard E. Sievers, Hubert H. Fok, Albert F. Candia, Kenneth J. Colley, Gonzalo Herradon, Laura Ezquerra, Thomas F. Deuel, and Randall J. Lee. Pleiotrophin Induces Formation of Functional Neovasculature In Vivo. Biochemical and Biophysical Research Communications. 2005; 332:1146-1152.
Karen L. Christman, Qizhi Fang, Michael S. Yee, Kandice R. Johnson, Richard E. Sievers, and Randall J. Lee. Enhanced Neovasculature Formation in Ischemic Myocardium Following Delivery of Pleiotrophin Plasmid in a Biopolymer. Biomaterials. 2005; 26:1139-44.
2004
Karen L. Christman, Andrew J. Vardanian, Qizhi Fang, Richard E. Sievers, Hubert H. Fok, and Randall J. Lee. Injectable Fibrin Scaffold Improves Cell Transplant Survival, Reduces Infarct Expansion, and Induces Neovasculature Formation in Ischemic Myocardium. Journal of the American College of Cardiology. 2004; 44:654-60.
Karen L. Christman, Hubert H. Fok, Richard E. Sievers, Qizhi Fang, and Randall J. Lee. Fibrin Glue Alone and Skeletal Myoblasts in a Fibrin Scaffold Preserve Cardiac Function after Myocardial Infarction. Tissue Engineering. 2004; 10:403-9.
2000
Jubilee R. Stewart, Karen L. Christman, and Catherine O'Brian. Effects of Resveratrol on the Autophosphorylation of Phorbol Ester-Responsive Protein Kinases: Inhibition of Protein Kinase D but Not Protein Kinase C Isozyme Autophosphorylation. Biochemical Pharmacology. 2000; 60(9):1355-9.